2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Chloride Cotransporter (NCC)

Sodium Chloride Cotransporter (NCC)

Sodium Chloride Cotransporter

Sodium chloride cotransporter (NCC), encoded by the SLC12A3 gene, is a member of the electroneutral cation–chloride cotransporter (CCC) family. NCC mediates Na+ and Cl− cotransport following a 1:1 stoichiometry.
NCC is a homodimer formed by two subunits. NCC-mediated ion transport is activated through the phosphorylation of conserved threonine and serine residues in the cytosolic N-terminal domain of the transporter.
Sodium chloride cotransporter (NCC) mediates the reabsorption of ultrafiltered sodium in the renal distal convoluted tubule that is essential for electrolyte balance, blood pressure regulation, and the pathophysiology of hypertension[1].

Sodium Chloride Cotransporter (NCC) Related Products (4):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15833
    Chlorthalidone
    		Inhibitor 99.76%
    Chlorthalidone is a thiazide-like diuretic used to treat hypertension.
    Chlorthalidone
  • HY-B1477
    Clopamide
    		Inhibitor 99.0%
    Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research.
    Clopamide
  • HY-119557
    Buthiazide
    		Activator 98.87%
    Buthiazide (Butizide) is a diuretic compound that can be used for high blood pressure research.
    Buthiazide
  • HY-111961
    Epitizide
    		Activator
    Epitizide, a benzothiadiazine, commonly found in combination Triamterene (HY-B0575), is used to produce diuresis.
    Epitizide