Sodium Chloride Cotransporter (NCC)
Sodium Chloride Cotransporter
Sodium chloride cotransporter (NCC), encoded by the SLC12A3 gene, is a member of the electroneutral cation–chloride cotransporter (CCC) family. NCC mediates Na+ and Cl− cotransport following a 1:1 stoichiometry.
NCC is a homodimer formed by two subunits. NCC-mediated ion transport is activated through the phosphorylation of conserved threonine and serine residues in the cytosolic N-terminal domain of the transporter.
Sodium chloride cotransporter (NCC) mediates the reabsorption of ultrafiltered sodium in the renal distal convoluted tubule that is essential for electrolyte balance, blood pressure regulation, and the pathophysiology of hypertension[1].
NCC is a homodimer formed by two subunits. NCC-mediated ion transport is activated through the phosphorylation of conserved threonine and serine residues in the cytosolic N-terminal domain of the transporter.
Sodium chloride cotransporter (NCC) mediates the reabsorption of ultrafiltered sodium in the renal distal convoluted tubule that is essential for electrolyte balance, blood pressure regulation, and the pathophysiology of hypertension[1].
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Sodium Chloride Cotransporter (NCC) Related Products (4)
Related Products (4)
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Epitizide
0 ImagesEpitizide, a benzothiadiazine, commonly found in combination Triamterene (HY-B0575), is used to produce diuresis.
